Cirrhosis is an abnormal condition where healthy tissue of the liver is replaced by scar tissue. The formation of scar tissue is irreversible and it eventually blocks the flow of blood through the liver. Cirrhosis is a slow progressing condition that occurs over years of liver damage. Cirrhosis, if not diagnosed early, can lead to advanced cirrhosis and liver cancer.
Cirrhosis is often dormant until extensive damage of the liver occurs, which determines the severity of symptoms. Some of the symptoms include fatigue, easy bleeding and bruising, ascites (accumulation of fluid in the abdomen), jaundice (yellowing of the eyes and skin), nausea, loss of appetite, weight loss, leg swelling and itchy skin.
Cirrhosis of the liver can lead to portal hypertension (high blood pressure in the blood vessels connecting the liver to digestive organs), which can cause bleeding in other blood vessels. Hepatic encephalopathy (high concentration of toxins in the blood) may also occur, secondary to the inability of the liver to detoxify the body. Some of the other complications include infections, kidney failure, diabetes, alteration in blood counts, enlargement of breasts in men, loss of muscle volume, premature menopause, and reduced oxygen in the blood.
Any damage to the liver can lead to cirrhosis. Viral infections such as hepatitis B, C or D, chronic alcohol abuse, and non-alcoholic steato-hepatitis (fatty liver disease) linked to diabetes and obesity are the most common causes of cirrhosis. Other causes may include:
Cirrhosis is often first detected during routine blood work. The usual diagnosis for cirrhosis may include liver function tests using blood samples, imaging studies (MRI, CT, and ultrasound), and biopsy where a sample of the liver is obtained and analysed under a microscope. Periodic imaging and blood tests are recommended to detect liver cancer.
The primary treatment for cirrhosis is to keep progression of liver damage in check, and treat the underlying cause. Severe cirrhosis may require you to be hospitalized. You will be instructed to stop drinking or enrol into a de-addiction program if your cirrhosis is because of alcohol dependency. You will need to control your blood sugar levels and lose weight if you are suffering from cirrhosis caused due to fatty liver disease. Your doctor will prescribe medication to treat hepatitis and other symptoms.
Cirrhosis can be prevented by:
Cirrhosis and surgery